Endocrine Abstracts

Introduction: Papillary thyroid carcinoma (PTC) is the most frequent endocrine malignancy. Apart from genetics, autoimmunity has been implicated in its pathogenesis. In this context, we set out study the role of Pro- inflammatory cytokines in PTC in South Indian population.Material and methods: This prospective case-control study was conducted on surgically managed PTC patients. Institutional ethical committee approval was obtained. Diagnosis of PTC was ...

Introduction: Thyroidectomy can performed by open or wide array of endoscopic techniques. Lack of uniform consensus on specific indications for each technique leads to confusion on ideal thyroidectomy technique. In this context, we analysed our experience with specific emphasis on deducing an algorithm on ideal technique for a given patient. Material and methods: This is a retrospective study conducted at a tertiary care endocrine surgery department in S...

Background: Preeclampsia (PE) continues tochallenge both the clinicians and researchers worldwide, as the existing knowledge on its etiopathology does not come up with an efficient and foolproof treatment regime due its progressive nature and uncertain diagnosis and prognosis. In this context, miRNAs represent a potential therapeutic target and a diagnostic tool.Objectives: Circulating microRNAs present in maternal blood play an important role in the eti...

Background: Thyroid cancers represent a diverse group of malignancies characterized by intricate genomic landscapes, necessitating advanced molecular investigations for a comprehensive understanding of their underlying genetic alterations. This study harnesses the power of Whole Exome Next-Generation Sequencing (WES) to unravel pan-exomic mutations in thyroid cancer samples. The primary objectives include correlating genomic changes with clinicopathologic features and unravell...

Objective: Anaplastic Thyroid Cancer (ATC) represents a formidable challenge in oncology due to its aggressive nature and high metastatic potential. This study delves into the quantitative assessment of microRNAs (miRNAs), specifically miRNA-149-5p, miRNA-548c-3p, and miRNA-3619-3p, to elucidate their roles in ATC progression and metastasis. Employing the robust technique of quantitative Reverse Transcription Polymerase Chain Reaction (RT-PCR), we meticulously examine the expr...